Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin
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چکیده
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 195 No. 5 827–838 www.jcb.org/cgi/doi/10.1083/jcb.201105144 JCB 827 Correspondence to Elisabeth Knust: [email protected]; or Shirin Meher Pocha: [email protected] Abbreviations used in this paper: Crb, Crumbs; dpe, day posteclosion; IF, immunofluorescence; IP, immunoprecipitate; MS, mass spectrometry; MyoV, myosin V; PRC, photoreceptor cell; Rh1, rhodopsin 1; Sdt, Stardust; UAS, upstream activating sequence; WB, Western blotting; WT, wild type. Introduction
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Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V
The evolutionarily conserved Crumbs (Crb) complex is crucial for photoreceptor morphogenesis and homeostasis. Loss of Crb results in light-dependent retinal degeneration, which is prevented by feeding mutant flies carotenoid-deficient medium. This suggests a defect in rhodopsin 1 (Rh1) processing, transport, and/or signaling, causing degeneration; however, the molecular mechanism of this remain...
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